Effects of Alternate Training for Limb Motor Skills on Brain-derived Neurotrophic Factor and Gait in Striatal Hemorrhage-induced Sprague-Dawley Rats
AUTHORS
Dae-hwan Lee,Dept. Physical Therapy, Daegu Univ., 201, Daegudae-ro, Jillyang-eup, Gyeongsan-si, Gyeongsangbuk-do, 38453, Republic of Korea
Jung-ho Lee,Dept. Physical Therapy, Kyungdong Univ., Bongpo-ri, Toseong-myeon, Goseong-gun, Gangwon-do, 219-705, Republic of Korea
Youn-bum Sung*,(Corresponding Author), Dept. Physical Therapy, Daegu Univ., 201, Daegudae-ro, Jillyang-eup, Gyeongsan-si, Gyeongsangbuk-do, 38453, Republic of Korea
ABSTRACT
In the brain hemorrhage causes damage to the patient's brain, and the impairment of neurotrophic factors and cognitive and motor disorders result in restrictions on daily and functional activities. In this study, we conducted abutment and familiar exercise in striatal hemorrhagic SD rat to compare neurotrophic factors and functional activities. The manifestation of BDNF in the brain of white mice was 107.08 ± 1.85 in the group that conducted the abutment movement and 104.97 ± 0.85 in the group that performed the familiar exercise, and was statistically significant. The Beam walking test scores were 4.53 0.5 0.52 points for the group that conducted the abutment movement and 4.80 ± 0.41 points for the group that performed the familiar movement, and statistically significant. It has been shown that alternating exercise can have a more positive effect on nerve recovery and motor function on striatal hemorrhage. This study suggests this alternative body motion pattern as a useful intervention for patients with cerebral hemorrhage.
KEYWORDS
Striatal hemorrhage, BDNF, Beam walking test, Treadmill, Swimming
REFERENCES
[1] A. Qureshi, A. Mendelow, and D. Hanley, “Intracerebral hemorrhage,” Lancet, vol.373, no.9675, pp.1632-1644, (2009) DOI: 10.1016/S0140-6736(09)60371-8(CrossRef)(Google Scholar)
[2] C. MacLellan, K. Langdon, K. Churchill, S. Granter-Button, and D. Corbett, “Assessing cognitive function after intracerebral hemorrhage in rats,” Behavioural Brain Research, vol.198, no.2, pp.321-328, (2009) DOI: 10.1016/j.bbr.2008.11.004(CrossRef)(Google Scholar)
[3] S. Mayer and F. Rincon, “Treatment of intracerebral hemorrhage,” Lancet Neurology, vol.4, no.10, pp.662-672, (2005)
[4] H. Eda, S. Sato, Y. Sasaki, A. Adachi, and M. Ghazizadeh, “Ischemic damage and subsequent proliferation of oligodendrocytes in hippocampal CA1 region following repeated brief cerebral ischemia,” Pathobiology, vol.76, no.4, pp.204-211, (2009) DOI: 10.1159/000218337(CrossRef)(Google Scholar)
[5] J. Jia, Y. Hu, Y. Wu, G. Liu, H. Yu, O. Zheng, D. Zhu, C. Xia, and Z. Cao, “Pre-ischemic treadmill training affects glutamate and gamma aminobutyric acid levels in the striatal dialysate of a rat model of cerebral ischemia,” Life Sciences, vol.84, no.15-16, pp.505-511, (2009) DOI: 10.1016/j.lfs. 2009.01.015(CrossRef)(Google Scholar)
[6] C. Fox, L. Ramig, M. Ciucci, S. Sapir, D. McFarland, and B. Farley, “The science and practice of LSVT/LOUD: neural plasticity-principled approach to treating individuals with Parkinson disease and other neurological disorders,” Speech Language Pathology, vol.27, no.4, pp.283-299, (2006) DOI: 10.1055/s-2006-955118(CrossRef)(Google Scholar)
[7] M. Voss, R. Prakash, K. Erickson, C. Basak, L. Chaddock, J. Kim, H. Alves, S. Heo, A. Szabo, S. White, T. Wojcicki, E. Mailey, N. Gothe, E. Olson, E. McAuley, and A. Kramer, “Plasticity of brain networks in a randomized intervention trial of exercise training in older adults,” Front Aging Neuroscience, vol.2, no.32, (2010) DOI: 10.3389/fnagi.2010.00032(CrossRef)(Google Scholar)
[8] L. Ma, B. Wang, S. Narayana, E. Hazeltine, X. Chen, D. Robin, P. Fox, and J. Xiong, “Changes in regional activity are accompanied with changes in inter-regional connectivity during 4 weeks motor learning,” Brain Research, vol.1318, pp.64-76, (2010) DOI: 10.1016/j.brainres.2009.12.073(CrossRef)(Google Scholar)
[9] S. Jang, “The effects of familiar exercise and novel exercise on brain recovery after intracerebral hemorrhage in rats,” Ph. D. dissertation, Rehabilitation Medicine department, Daegu University, Gyeongsan-si, Gyeongsangbuk-do, Republic of Korea, (2012)
[10] K. Cowansage, J. LeDoux, and M. Monfils, “Brain-derived neurotrophic factor: a dynamic gate keeper of neural plasticity,” Current Molecular Pharmacology, vol.3, no.1, pp.12-29, (2010) DOI: 10.2174/1874467211003010012(CrossRef)(Google Scholar)
[11] G. Nagappan and B. Lu, “Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implications,” Trends in Neurosciences, vol.28, no.9, pp.464-471, (2005) DOI: 10.1016/j.tins.2005.07.003(CrossRef)(Google Scholar)
[12] G. Brooks and T. White, “Determination of metabolic and heart rate responses of rats to treadmill exercise,” Journal of applied physiology: respiratory, environmental and exercise physiology, vol.45, no.6, 1009-1015, (1928) DOI: 10.1152/jappl.1978.45.6.1009(CrossRef)(Google Scholar)
[13] K. Chu, J. Eng, A. Dawson, J. Harris, A. Ozkaplan, and S. Gylfadottir, “Water-based exercise for cardiovascular fitness in people with chronic stroke: a randomized controlled trial,” Archives of Physical Medicine and Rehabilitation, vol.85, no.6, pp.870-874, (2004) DOI: 10.1016/j.apmr.2003.11.001(CrossRef)(Google Scholar)
[14] D. Kwon, “Effects of swimming training on immune function of growing rats fed a high-fat diet,” Journal of the Human-Environment System, vol.8, no.1, pp.13-18, (2005) DOI: 10.1618/jhes.8.13(CrossRef)(Google Scholar)
[15] M. Greenberg, B. Xu, B. Lu, and B. Hempstead, “New insights in the biology of BDNF synthesis and release: implications in CNS function,” Journal of Neuroscience, vol.29, no.41, pp.12764-12767, (2009) DOI: 10.1523/JNEUROSCI.3566-09.2009(CrossRef)(Google Scholar)
[16] R. Wang, Y. Yang, and S. Yu, “Protective effects of treadmill training on infarction in rats,” Brain Research (2001), vol.922, no.1, pp.140-143, (2001) DOI: 10.1016/s0006-8993(01)03154-7(CrossRef)(Google Scholar)
[17] S. Allen and D. Dawbarn, “Clinical relevance of the neurotrophins and their receptors,” Clinical Science (London, England), vol.110, no.2, pp.175-191, (2006) DOI: 10.1042/CS20050161(CrossRef)(Google Scholar)
[18] C. Bramham and E. Messaoudi, “BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis,” Progress in Neurobiology, vol.76, no.2, pp.99-125, (2005) DOI: 10.1016/j.pneurobio.2005.06.003(CrossRef)(Google Scholar)
[19] M. Sasaki, C. Radtke, A. Tan, P. Zhao, H. Hamada, K. Houkin, O. Honmou, and J. Kocsis, “BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury,” Journal of Neuroscience, vol.29, no.47, pp.14932-14941, (2009) DOI: 10.1523/JNEUROSCI.2769-09.2009(CrossRef)(Google Scholar)