Therapeutic Intervention for Restoration of Sensory and Motor Function after Central Nervous System Injury
AUTHORS
Jung-Ho Lee, Department of Physical Therapy, Kyungdong University, Bongpo-ri, Toseong-myeon, Goseong-gun, Gangwon-do, Korea
ABSTRACT
The objective of this study was to investigate the effects of extracorporeal shock wave therapy, on the expression of neurotrophin-3, and C-Fos in the central nervous system injury of rats. In this study, 16 eight-week-old, Sprague-Dawley origin male white rats weighing 250-300g were tested. For low intensity extracorporeal shock wave therapy, a magnetic-type extracorporeal shock wave therapy equipment (HAEMIL, Soltar, Korea) was used. ESWT was applied to the gastrocnemius muscle of the injuried side hind limb. Western blot analysis was analyzed for the evaluation of the NT-3, and C-Fos. Before the experiment, the spinal cords of the experimental and control groups were extracted and pre-evaluated. Spinal cords were extracted after all experiments to extract neurotrophic factors from the experimental and control groups. The change amount of NT-3 and C-Fos expression was statistically significantly difference in the ESWT group that received shock wave compared to the control group. In the comparison of treatment effects of the therapeutic methods, the experimental group showed a significant larger change compared to the control group.
KEYWORDS
Sensory, Motor, Function, Therapy, Restoration
REFERENCES
[1] Y. Zhou, Y. Wang, J. Wang, R. Anne Stetler, and Q. W. Yang, “Inflammation in intracerebral hemorrhage: from mechanisms to clinical translation,” Progress in Neurobiology, vol.115, pp.25-44, (2014) DOI: 10.1016/j.pneurobio.2013.11.003.(CrossRef)(Google Scholar)
[2] H. R. Rostami, M. Akbarfahimi, A. M. Hassani, A. R. Akbarinia, and S. Samani, “Occupation-based intervention versus rote exercise in modified constraint-induced movement therapy for patients with median and ulnar nerve injuries: A randomized controlled trial,” Clinical Rehabilitation, vol.31, pp.1087-1097, (2017) DOI: 10.1177/0269215516672276.(CrossRef)(Google Scholar)
[3] A. Santamato, A. Notarnicola, F. Panza, M. Ranieri, M. F. Micello, P. Manganotti, B. Moretti, F. Fortunato, S. Filoni, and P. Fiore, “SBOTE study: extracorporeal shock wave therapy versus electrical stimulation after botulinum toxin type an injection for post-stroke spasticity-a prospective randomized trial,” Ultrasound in Medicine & Biology, vol.39, pp.283-291, (2013) DOI: 10.1016/j.ultrasmedbio.2012.09.019.(CrossRef)(Google Scholar)
[4] F. Mori, G. Koch, C. Foti, G. Bernardi, and D. Centonze, “The use of repetitive transcranial magnetic stimulation (rTMS) for the treatment of spasticity,” Progress in Brain Research, vol.175, pp.429-439, (2009) DOI: 10.1016/S0079-6123(09)17528-3.(CrossRef)(Google Scholar)
[5] T. G. Kim, S. H. Bae, G. Y. Kim, and K. Y. Kim, “The effects of extracorporeal shock wave therapy on stroke patients with plantar fasciitis,” Journal of Physical Therapy Science, vol.27, pp.523-526, (2015) DOI: 10.1589/jpts.27.523.(CrossRef)(Google Scholar)
[6] S. Mense, and U. Hoheisel, “Shock wave treatment improves nerve regeneration in the rat,” Muscle Nerve, vol.47, pp.702-710, (2013) DOI: 10.1002/mus.23631.(CrossRef)(Google Scholar)
[7] T. Hausner, K. Pajer, G. Halat, R. Hopf, R. Schmidhammer, H. Redl, and A. Nógrádi, “Improved rate of peripheral nerve regeneration induced by extracorporeal shock wave treatment in the rat,” Experimental Neurology, vol.236, pp.363-370, (2012) DOI: 10.1016/j.expneurol.2012.04.019.(CrossRef)(Google Scholar)
[8] R. Mittermayr, V. Antonic, J. Hartinger, H. Kaufmann, H. Redl, L. Téot, A. Stojadinovic, and W. Schaden, “Extracorporeal shock wave therapy (ESWT) for wound healing: technology, mechanisms, and clinical efficacy,” Wound Repair and Regeneration, vol.20, pp.456-465, (2012) DOI: 10.1111/j.1524-475X.2012.00796.x.(CrossRef)(Google Scholar)